Cold agglutinin disease following SARS‐CoV‐2 and Mycoplasma pneumoniae co‐infections

Transient cold agglutinin disease with mycoplasma infection.

Cold agglutinins are autoantibodies and are often present in the sera of healthy individuals. They assume importance when the thermal reactivity of these antibodies approaches body temperature. This communication describes a case of cold hemagglutinin disease with Mycoplasma pneumoniae infection detected during routine laboratory investigations. The patient was managed conservatively.

Cold agglutinin disease.

Cold agglutinin disease is a rare and poorly understood disorder affecting 15% of patients with autoimmune hemolytic anemia. We reviewed the clinical and pathologic features, prognosis, and management in the literature and describe our institutional experience to improve strategies for accurate diagnosis and treatment. Retrospective analysis identified 89 patients from our institution with cold...

A case of chronic renal failure followed by cold agglutinin due to Mycoplasma pneumoniae infection.

Reliability of cold agglutinin test (CAT) for diagnosis of Mycoplasma pneumoniae pneumonia in hospitalized patients

Introduction: M. pneumoniae is one of the causative agents of primary atypical pneumonia. This infection causes 20-40% of community acquired pneumonia and is associated with an array of extrapulmonary manifestations. There is a need for a rapid diagnostic test in order to prescribe prompt and appropriate antibiotic therapy. Even though isotype specific antibody testing provides definitive diagn...

Severe acrocyanosis precipitated by cold agglutinin secondary to infection with Mycoplasma pneumoniae in a pediatric patient

This is the first report describing a severe form of cold agglutinin-induced acrocyanosis with cutaneous necrosis after Mycoplasma infection in a 9-year-old patient without any other severe symptoms and laboratory alterations. We also present the results of two non-invasive methods used to determine the viability of tissues, degree of tissue perfusion impairment, and the responsiveness of the m...